Centennial Investors are led by a group of five officers (shown below). The group has a part-time executive director and a graduate but no other employees. CI benefits from various forms of support provided by several organizations (described on the Partners page).

The work of CI is largely carried out by permanent committees as well as special-focus task forces. The committees focus primarily on seeking applications for funding from promising startups, screening applications, membership development, and collaborating with entrepreneurial-support organizations in Missouri. Currently, task forces are working on membership development, increasing deal flow, and collaborations with other angel organizations in Missouri.